Everything about Guanosine Triphosphate totally explained
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Guanosine-5'-triphosphate (
GTP) is a
purine nucleotide. One role is as substrate for the synthesis of
RNA during
transcription. Its structure is similar to that of the
guanine nucleoside, the only difference being that there are three extra
phosphate groups added on to the 5' carbon.
It also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of
ATP, but more specific. It is used as a source of energy for
protein synthesis.
GTP is essential to
signal transduction, particularly with
G-proteins, where it's converted to
GDP (guanosine diphosphate) through the action of
GTPases.
Energy transfer
GTP is involved in energy transfer within the cell. For instance, a GTP molecule is generated by one of the enzymes in the
citric acid cycle. This is tantamount to the generation of one molecule of
ATP, since GTP is readily converted to ATP.
cGTP
Cyclic guanosine triphosphate (cGTP) helps
cyclic adenosine monophosphate (cAMP) activate
cyclic nucleotide-gated ion channels in the
olfactory system .
Further Information
Get more info on 'Guanosine Triphosphate'.
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